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CREB and NF-kappaB transcription factors regulate sensitivity to excitotoxic and oxidative stress induced neuronal cell death.
Zou J, Crews F. Zou J, et al. Cell Mol Neurobiol. 2006 Jul-Aug;26(4-6):385-405. doi: 10.1007/s10571-006-9045-9. Epub 2006 Apr 22. Cell Mol Neurobiol. 2006. PMID: 16633891
We hypothesize that the vital state of neurons is regulated in part by two key transcription factors, CREB and NF-kappaB. ...Together these studies suggest that neurotoxicity through glutamate-NMDA receptors or oxidative stress is depende …
We hypothesize that the vital state of neurons is regulated in part by two key transcription factors, CREB and N …
Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro.
Lewerenz J, Albrecht P, Tien ML, Henke N, Karumbayaram S, Kornblum HI, Wiedau-Pazos M, Schubert D, Maher P, Methner A. Lewerenz J, et al. J Neurochem. 2009 Oct;111(2):332-43. doi: 10.1111/j.1471-4159.2009.06347.x. Epub 2009 Aug 18. J Neurochem. 2009. PMID: 19694903 Free article.
In amyotrophic lateral sclerosis, down-regulation of the astrocyte-specific glutamate excitatory amino acid transporter 2 is hypothesized to increase extracellular glutamate, thereby leading to excitotoxic motor neuron death. ...Lack of intracellular c …
In amyotrophic lateral sclerosis, down-regulation of the astrocyte-specific glutamate excitatory amino acid transporter 2 is hypothes …