Development of autoimmune insulitis is prevented in E alpha d but not in A beta k NOD transgenic mice

M Uehira; M Uno; T Kürner; H Kikutani; K Mori; T Inomoto; T Uede; J Miyazaki; H Nishimoto; T Kishimoto

doi:10.1093/intimm/1.2.209

Development of autoimmune insulitis is prevented in E alpha d but not in A beta k NOD transgenic mice

Int Immunol. 1989;1(2):209-13. doi: 10.1093/intimm/1.2.209.

Authors

M Uehira¹, M Uno, T Kürner, H Kikutani, K Mori, T Inomoto, T Uede, J Miyazaki, H Nishimoto, T Kishimoto, et al.

Affiliation

¹ Shionogi Research Laboratory, Shionogi Co. Ltd, Osaka, Japan.

PMID: 2562156
DOI: 10.1093/intimm/1.2.209

Abstract

Two lines of E alpha d-expressing NOD mice were established by continuously backcrossing [E alpha d B6 transgenic mice x NOD] F1 to parental NOD or directly microinjecting the E alpha d gene into fertilized NOD eggs. Similarly, A beta k-expressing transgenic NOD mice were produced. Subsequent histological examination of pancreatic tissues revealed that autoimmune insulitis was prevented in E alpha d backcross and transgenic mice but not in A beta k transgenic mice.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Autoimmune Diseases / genetics*
Autoimmune Diseases / immunology
Autoimmune Diseases / pathology
Crosses, Genetic
Diabetes Mellitus, Experimental / genetics*
Diabetes Mellitus, Experimental / immunology
Diabetes Mellitus, Experimental / pathology
Female
Histocompatibility Antigens Class II / genetics*
Islets of Langerhans / pathology
Male
Mice
Mice, Transgenic

Substances

Histocompatibility Antigens Class II
I-E-antigen