HNA-1a, HNA-1b and HNA-1c gene frequencies in Argentineans

Tissue Antigens. 2008 May;71(5):475-7. doi: 10.1111/j.1399-0039.2008.01034.x.

Abstract

Human neutrophil antigens (HNA) are polymorphic structures located in the neutrophil membrane. The neutrophil-specific antigens HNA-1a (NA1), 1b (NA2) and 1c (SH) are well-recognized allotypic forms of FcgammaRIIIb and the most frequent targets of neutrophil alloantibodies. The aim of this study was to determine the gene frequencies of the neutrophil-specific antigens belonging to the HNA-1 system in blood donors and Toba Amerindians from Rosario, Argentina. Two hundred and eighteen unrelated healthy Argentinean blood donors and Toba Amerindians from Rosario were typed for HNA-1a, HNA-1b and HNA-1c using polymerase chain reaction with sequence-specific primers. For the Argentinean blood donors, the HNA-1a and HNA-1b gene frequencies were 0.44 and 0.56 and for the Amerindians Toba were 0.77 and 0.23, respectively. The HNA-1c antigen is present in 4.7% (gene frequency=0.023) of the blood donors but in none of the Amerindian individuals. The present data showed that the HNA-1 allele frequencies in the major population and the Toba Amerindians from Rosario are similar to those described in European and others distant Amerindians populations, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Argentina
  • Ethnicity / genetics*
  • Gene Frequency*
  • Genotype
  • Humans
  • Indians, South American / genetics*
  • Isoantigens / genetics*
  • Neutrophils / immunology*

Substances

  • Isoantigens
  • neutrophil-specific antigen NA1, human