For fundamental understanding of pathophysiological mechanisms as well as absorption and transport processes of drug molecules in the human body, human-relevant models are indispensable. Such models are required for predictive testing of novel medicines. For many diseased states, animal models do not adequately mimic human pathophysiology, thus leading to high attrition rates in preclinical development.

Dr. Windberg's research is focused on in vitro models based on human cells and tissues balancing the required level of biological complexity and the applicability for valid and predictive testing. To address the individual scientific demands, her group has established models ranging from cell monolayers up to complex three-dimensional organotypic cultures integrating multiple human cell types as well as ex vivo tissue biopsies. Besides the use of established hydrogels, her labs has develop bio-inspired, functional materials to simulate the human extracellular matrix for cultivating cells. The models mimic healthy, physiological states, but also disease-relevant conditions, such as inflammation and infection as well as defects like wounds. Their application ranges from basic research and investigation of material-cell interactions up to testing of novel medicines in a (patho)physiologically relevant environment. Particular emphasis is put on the analysis of therapeutic effectiveness, cytotoxicity and cellular uptake to accelerate the translation of these models into clinical application.


DATE: Oct 31, 2018
Time:  7pm - 10pm
Location: Biologicum Seminar Room, -1.201, Campus Riedberg

Registration limit: No