SciFinder Quiz 4
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SciFinder® is your portal to science and technology related information, providing easy access to the most trusted collection of chemical substances, reactions and literature references in the world that is curated by expert scientists, not robots. Leading pharmaceutical, biotechnology and chemical corporations as well as top academic institutions and government laboratories rely on SciFinder to keep up to date on and leverage the latest advances in science.
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Quiz Questions
SciFinder access link: https://scifinder.cas.org/
A SciFinder username and password needs to be created in order to access SciFinder. Please ensure you are using Mahidol University network, click here (https://tinyurl.com/mahidolSF) and follow the steps to register for your SciFinder account using your Mahidol University email address.
1. What is your SciFinder username? *
Medical adherence is one of the key factors that compromises the efficacy of antiretroviral therapy. Currently, there are no long lasting antiretroviral drugs developed that will avoid the need for daily administration. You have been assigned a project to explore alternative drug delivery methods or formulations that will allow a weekly oral administration of antiretroviral drugs to ease the burden of daily medical adherence.Use SciFinder to help you get a better understanding of this research area and plan for your project.
2. Find out what are the antiretroviral drugs that are currently being used for treatment of HIV. Run a Research Topic search on "antiretroviral drugs for treatment of HIV".
Which of the drugs below have been studied as antiretroviral drugs for treatment of HIV (you may choose more than one answer)? *
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3. Next, we want to find literature related to bioavailability of the drug Efavirenz. Run a substance identifier search on "Efavirenz".
What are some processes that may be used to improve bioavailability (you may choose more than one answer)? *
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4. We have obtained a mass spectrum from our analysis of Efavirenz from human blood samples and observed mass peaks of m/z=311. Run a substructure search on Efavirenz in SciFinder to find any literature reported metabolites that match the mass we obtained from our analysis. We can narrow down the answer set to those that match our desired mass (or molecular weight) range of "330-332".
Which of the structures below are reported in literature that matches our desired mass peak (you may choose more than one answer)? *
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5. A common  strategy to block metabolic sites to increase the amount of the active drug in the body is to replace the H with F atom. Find out if there are any literature reports on the synthesis of the analogue of Efavirenz below.
Are there any reported reactions on the synthesis of the compound above? *
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