Hydrogen sulfide: physiological properties and therapeutic potential in ischaemia

Br J Pharmacol. 2015 Mar;172(6):1479-93. doi: 10.1111/bph.12869.

Abstract

Hydrogen sulfide (H2 S) has become a molecule of high interest in recent years, and it is now recognized as the third gasotransmitter in addition to nitric oxide and carbon monoxide. In this review, we discuss the recent literature on the physiology of endogenous and exogenous H2 S, focusing upon the protective effects of hydrogen sulfide in models of hypoxia and ischaemia.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gasotransmitters / metabolism
  • Humans
  • Hydrogen Sulfide / administration & dosage
  • Hydrogen Sulfide / metabolism*
  • Hypoxia / physiopathology*
  • Hypoxia / therapy
  • Ischemia / physiopathology*
  • Ischemia / therapy

Substances

  • Gasotransmitters
  • Hydrogen Sulfide