The role of H2S bioavailability in endothelial dysfunction

Trends Pharmacol Sci. 2015 Sep;36(9):568-78. doi: 10.1016/j.tips.2015.05.007. Epub 2015 Jun 9.

Abstract

Endothelial dysfunction (EDF) reflects pathophysiological changes in the phenotype and functions of endothelial cells that result from and/or contribute to a plethora of cardiovascular diseases. We review the role of hydrogen sulfide (H2S) in the pathogenesis of EDF, one of the fastest advancing research topics. Conventionally treated as an environment pollutant, H2S is also produced in endothelial cells and participates in the fine regulation of endothelial integrity and functions. Disturbed H2S bioavailability has been suggested to be a novel indicator of EDF progress and prognosis. EDF manifests in different forms in multiple pathologies, but therapeutics aimed at remedying altered H2S bioavailability may benefit all.

Keywords: cystathionine gamma-lyase; endothelium-derived hyperpolarizing factor; gasotransmitters; heme oxygenase-1; hydrogen sulfide; nitric oxide.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Endothelium, Vascular / metabolism*
  • Endothelium, Vascular / physiology
  • Endothelium, Vascular / physiopathology
  • Free Radicals / metabolism
  • Humans
  • Hydrogen Sulfide / metabolism*
  • Vascular Diseases / etiology
  • Vascular Diseases / metabolism*

Substances

  • Free Radicals
  • Hydrogen Sulfide