Molecular Insight into Dengue Virus Pathogenesis and Its Implications for Disease Control

Michael S Diamond; Theodore C Pierson

doi:10.1016/j.cell.2015.07.005

Molecular Insight into Dengue Virus Pathogenesis and Its Implications for Disease Control

Cell. 2015 Jul 30;162(3):488-92. doi: 10.1016/j.cell.2015.07.005.

Authors

Michael S Diamond¹, Theodore C Pierson²

Affiliations

¹ Departments of Medicine, Molecular Microbiology, Pathology & Immunology, Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: diamond@wusm.wustl.edu.
² Viral Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: piersontc@mail.nih.gov.

Abstract

Dengue virus (DENV) is a mosquito-transmitted RNA virus that infects an estimated 390 million humans each year. Here, we review recent advances in our understanding of the biology of DENV and describe knowledge gaps that have impacted the development of effective vaccines and therapeutics.

Publication types

Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Dengue / immunology
Dengue / prevention & control
Dengue / therapy
Dengue / virology*
Dengue Vaccines / immunology
Dengue Virus / immunology
Dengue Virus / physiology*
Humans
Immune Evasion

Substances

Dengue Vaccines

Abstract

Publication types

MeSH terms

Substances

Grants and funding