Acetogenins from Annonaceae, inhibitors of mitochondrial complex I

M C Zafra-Polo; M C González; E Estornell; S Sahpaz; D Cortes

doi:10.1016/0031-9422(95)00836-5

Acetogenins from Annonaceae, inhibitors of mitochondrial complex I

Phytochemistry. 1996 May;42(2):253-71. doi: 10.1016/0031-9422(95)00836-5.

Authors

M C Zafra-Polo¹, M C González, E Estornell, S Sahpaz, D Cortes

Affiliation

¹ Departamento de Farmacología (Farmacognosia y Farmacodinamia), Facultad de Farmacia, Universidad de Valencia, Spain.

PMID: 8688168
DOI: 10.1016/0031-9422(95)00836-5

Abstract

One-hundred and twenty-eight different linear, epoxy, mono-tetrahydrofuran, bis-tetrahydrofuran or tri-tetrahydrofuran acetogenins have been isolated from the Annonaceae. These new secondary metabolites are potent cytotoxic inhibitors of the mitochondrial NADH:ubiquinone oxidoreductase (complex I of the respiratory chain).

Publication types

Comparative Study
Research Support, Non-U.S. Gov't
Review

MeSH terms

Enzyme Inhibitors / chemistry
Enzyme Inhibitors / isolation & purification*
Enzyme Inhibitors / pharmacology
Furans / chemistry
Furans / isolation & purification*
Furans / pharmacology
Mitochondria / enzymology*
Molecular Structure
NAD(P)H Dehydrogenase (Quinone) / antagonists & inhibitors*
Plants*
Plants, Medicinal
Species Specificity

Substances

Enzyme Inhibitors
Furans
NAD(P)H Dehydrogenase (Quinone)