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Redox-crippled MitoQ potently inhibits breast cancer and glioma cell proliferation - PubMed

pubmed.ncbi.nlm.nih.gov › ...
Aug 20, 2023 · MitoQ, sold as a nutritional supplement, prevents breast cancer recurrence. It potently inhibited tumor growth and tumor cell proliferation in preclinical ...

Acute high-dose MitoQ does not increase urinary kidney injury markers in healthy adults: a randomized crossover trial - PubMed

pubmed.ncbi.nlm.nih.gov › ...
Jan 1, 2024 · NEW & NOTEWORTHY We found acute high-dose mitochondria-targeted antioxidant (MitoQ) supplementation was not nephrotoxic and had no effect on markers of acute ...

Chronic mitochondria antioxidant treatment in older adults alters the circulating milieu to improve endothelial cell function and mitochondrial oxidative stress - PubMed

pubmed.ncbi.nlm.nih.gov › ...
Jul 1, 2023 · Here, we show that MitoQ supplementation leads to changes in the circulating milieu (plasma), including reductions in oxidized low-density lipoprotein that ...

Mitochondrial‐targeted antioxidant ingestion acutely blunts VO2max in physically inactive females - PMC - NCBI

www.ncbi.nlm.nih.gov › PMC10703545
Dec 7, 2023 · Thus, the primary aim of this study was to examine if MitoQ alters the metabolic responses during submaximal and maximal exercise. Our hypothesis was that MitoQ ...

Selpercatinib combination with the mitochondria-targeted antioxidant MitoQ effectively suppresses RET-mutant thyroid cancer - PubMed

pubmed.ncbi.nlm.nih.gov › ...
Feb 20, 2024 · We show that selpercatinib significantly increased Δψm, and its combination with MitoQ synergistically suppressed RET-mutated human thyroid tumor cells, which ...

The mitochondria-targeted antioxidant "MitoQ" preserves quality and reproductive performance of ram spermatozoa cryopreserved in soybean lecithin-based extender - PubMed

pubmed.ncbi.nlm.nih.gov › ...
Sep 15, 2023 · This study was performed to investigate the effect of the novel mitochondria-targeted antioxidant "MitoQ" on ram sperm quality and fertility potential during ...

Effects of a mitochondrial-targeted ubiquinol on vascular function and exercise capacity in chronic kidney disease: a randomized controlled pilot study - PubMed

pubmed.ncbi.nlm.nih.gov › ...
Oct 1, 2023 · MitoQ did not affect exercise capacity. In conclusion, this study demonstrates the potential for a MitoQ to improve vascular function in CKD. The findings hold ...

MitoQ alleviates hippocampal damage after cerebral ischemia: The potential role of SIRT6 in regulating mitochondrial dysfunction and neuroinflammation - PubMed

pubmed.ncbi.nlm.nih.gov › ...
Sep 1, 2023 · The present study explored the neuroprotective effect of the mitochondrial-targeted antioxidant, Mitoquinol (MitoQ), against hippocampal neuronal loss in an ...

Acute effects of MitoQ on vascular endothelial function are influenced by cardiorespiratory fitness and baseline FMD in middle-aged and older adults - PubMed

pubmed.ncbi.nlm.nih.gov › ...
Apr 4, 2024 · Abstract. A key mechanism promoting vascular endothelial dysfunction is mitochondrial-derived reactive oxygen species (mtROS). Aerobic exercise preserves ...

MitoQ combats tumor cell progression in Ehrlich ascites carcinoma mice: A crosstalk between mitochondrial oxidative status, mitophagy, and NF-κB signaling - PubMed

pubmed.ncbi.nlm.nih.gov › ...
Oct 15, 2023 · This study suggests that MitoQ combated tumor cell survival and progression in EAC mice by maintaining mtROS and restoring mitophagy, thereby attenuation of ...