The complex anatomy of invaginated teeth makes their endodontic treatment difficult. The case described here reports the successful management of an invaginated tooth presenting with a lateroradicular lesion. After the root was surgically exposed and the radicular defect was cleaned, gutta percha was sealed with a zinc oxide eugenol cement, heat-compacted under 5 degrees, and then cold-burnished. The osseous cavity was filled with Biocorail. Radiographs at 1 month and 5 years show periapical healing with osseous formation. This procedure, resulting in minimal loss of hard tissues, permitted retention of the tooth.