Dissociated glucocorticoid receptor ligands.

Schäcke H; Rehwinkel H

Dissociated glucocorticoid receptor ligands.

Schäcke H ¹,

Rehwinkel H

Affiliations

1. Schering AG, Corporate Research, Müllerstrasse 178, 13342 Berlin, Germany.
Authors
Schäcke H¹
(1 author)

Current Opinion in Investigational Drugs (London, England : 2000), 01 May 2004, 5(5):524-528
PMID: 15202726

Review

Abstract

Since their introduction, the extraordinary importance of glucocorticoids in the treatment of inflammatory and autoimmune disorders is undisputed, despite their known undesirable side effects. In the 1990s, major scientific progress was made, with the discovery that positive and negative regulation of gene expression via the glucocorticoid receptor are mediated by different mechanisms. This discovery led to the assumption that it may be possible to dissociate the therapeutic effects of glucocorticoids from their side effects by using ligands which specifically or preferentially address one of the two pathways. Several pharmaceutical companies are currently pursuing this goal.

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Discovery of new selective glucocorticoid receptor agonist leads.
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Articles in the Open Access Subset are available under a Creative Commons license. This means they are free to read, and that reuse is permitted under certain circumstances. There are six different Creative Commons licenses available, see the copyright license for this article to understand what type of reuse is permitted.
Free full text in Europe PMC

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Dissociated glucocorticoid receptor ligands.

Affiliations

Authors

Abstract

Citations & impact

Impact metrics

Citations of article over time

Article citations

Glucocorticoid/Adiponectin Axis Mediates Full Activation of Cold-Induced Beige Fat Thermogenesis.

Glucose, lipid and oxidative stress lowering activity of the aqueous extract from leafy stems of Cissus polyantha Gilg & Brandt in dexamethasone-induced hyperglycemia in rats.

Discovery of new selective glucocorticoid receptor agonist leads.

Advances in pharmacotherapy for allergic conjunctivitis.

Therapeutic targeting of eosinophil adhesion and accumulation in allergic conjunctivitis.

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