Preservation solutions for solid organ transplantation

Mini Rev Med Chem. 2006 Oct;6(10):1081-90. doi: 10.2174/138955706778560148.

Abstract

Solid organ transplantation was one of the greatest medical advances of the 20th century. Current preservation technology falls short of maintaining organs ex vivo in perpetuity. This review examines the biochemical basis of organ degradation in response to ischaemia, preservation solution composition and potential future organ preservation technology.

Publication types

  • Review

MeSH terms

  • Calcium / chemistry
  • Colloids / chemistry
  • Humans
  • Hydrogen-Ion Concentration
  • Organ Preservation Solutions / chemistry*
  • Organ Preservation Solutions / standards
  • Organ Transplantation*
  • Reactive Oxygen Species / chemistry
  • Reperfusion Injury / prevention & control

Substances

  • Colloids
  • Organ Preservation Solutions
  • Reactive Oxygen Species
  • Calcium