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Prediabetes/early diabetes-associated neuropathy predominantly involves sensory small fibres.
Divisova S, Vlckova E, Hnojcikova M, Skorna M, Nemec M, Dubovy P, Dusek L, Jarkovsky J, Belobradkova J, Bednarik J. Divisova S, et al. J Peripher Nerv Syst. 2012 Sep;17(3):341-50. doi: 10.1111/j.1529-8027.2012.00420.x. J Peripher Nerv Syst. 2012. PMID: 22971096
The subclinical DSPN criteria based on NC abnormalities were met in 4.2% eDM2 patients, while the proportion of preDM and eDM2 cases with subclinical sensory small-fibre involvement documented by IENFD reached 12.5% and 22.9% compared with 2.5% controls (p = 0.005 f …
The subclinical DSPN criteria based on NC abnormalities were met in 4.2% eDM2 patients, while the proportion of preDM and eDM2 …
Demethylation of ERECTA receptor genes by IBM1 histone demethylase affects stomatal development.
Wang Y, Xue X, Zhu JK, Dong J. Wang Y, et al. Development. 2016 Dec 1;143(23):4452-4461. doi: 10.1242/dev.129932. Epub 2016 Oct 3. Development. 2016. PMID: 27697902 Free PMC article.
Loss-of-function ibm1 and edm2 mutant plants display a wide range of developmental defects, but little is known about which developmentally important genes are regulated by IBM1 and EDM2. Here, we show that both ibm1 and edm2 mutants display defects in produc …
Loss-of-function ibm1 and edm2 mutant plants display a wide range of developmental defects, but little is known about which developme …
EMSY-like genes are required for full RPP7-mediated race-specific immunity and basal defense in Arabidopsis.
Tsuchiya T, Eulgem T. Tsuchiya T, et al. Mol Plant Microbe Interact. 2011 Dec;24(12):1573-81. doi: 10.1094/MPMI-05-11-0123. Mol Plant Microbe Interact. 2011. PMID: 21830950 Free article.
Transcript levels of the disease-resistance gene RPP7 are enhanced by EDM2 while those of the floral suppressor FLC are repressed by EDM2. ...Domain architectures of EDM2 as well as AtEML proteins suggest roles of these proteins in the regulation of chromatin …
Transcript levels of the disease-resistance gene RPP7 are enhanced by EDM2 while those of the floral suppressor FLC are repressed by …
Mutations in EDM2 selectively affect silencing states of transposons and induce plant developmental plasticity.
Tsuchiya T, Eulgem T. Tsuchiya T, et al. Sci Rep. 2013;3:1701. doi: 10.1038/srep01701. Sci Rep. 2013. PMID: 23609044 Free PMC article.
We previously reported on the A. thaliana gene EDM2, which is required for several developmental processes and race-specific immunity. Although EDM2 encodes a nuclear protein with features commonly observed in epigenetic factors, its role in chromatin silencing rema …
We previously reported on the A. thaliana gene EDM2, which is required for several developmental processes and race-specific immunity …
The Arabidopsis defense component EDM2 affects the floral transition in an FLC-dependent manner.
Tsuchiya T, Eulgem T. Tsuchiya T, et al. Plant J. 2010 May;62(3):518-28. doi: 10.1111/j.1365-313X.2010.04169.x. Epub 2010 Feb 9. Plant J. 2010. PMID: 20149132 Free article.
In addition, we found that EDM2 has a promoting effect on the floral transition. We further found that the protein kinase WNK8 physically interacts with EDM2 in the nucleus. Unlike EDM2, which serves as a substrate of this kinase, WNK8 appears not to be requi …
In addition, we found that EDM2 has a promoting effect on the floral transition. We further found that the protein kinase WNK8 physic …
The Arabidopsis PHD-finger protein EDM2 has multiple roles in balancing NLR immune receptor gene expression.
Lai Y, Lu XM, Daron J, Pan S, Wang J, Wang W, Tsuchiya T, Holub E, McDowell JM, Slotkin RK, Le Roch KG, Eulgem T. Lai Y, et al. PLoS Genet. 2020 Sep 14;16(9):e1008993. doi: 10.1371/journal.pgen.1008993. eCollection 2020 Sep. PLoS Genet. 2020. PMID: 32925902 Free PMC article.
We further found EDM2 to have a global role in NLR expression control. Besides serving as a positive regulator of RPP7 and a small number of other NLR genes, EDM2 acts as a suppressor of a multitude of additional NLR genes. ...Moreover, we are providing new insights …
We further found EDM2 to have a global role in NLR expression control. Besides serving as a positive regulator of RPP7 and a small nu …
EDM2 is required for RPP7-dependent disease resistance in Arabidopsis and affects RPP7 transcript levels.
Eulgem T, Tsuchiya T, Wang XJ, Beasley B, Cuzick A, Tör M, Zhu T, McDowell JM, Holub E, Dangl JL. Eulgem T, et al. Plant J. 2007 Mar;49(5):829-39. doi: 10.1111/j.1365-313X.2006.02999.x. Epub 2007 Jan 23. Plant J. 2007. PMID: 17253987 Free article.
Mutations of EDM2 phenocopy RPP7 mutations, but do not affect other tested disease resistance genes. ...In edm2 mutants both constitutive and HpHiks1-induced RPP7 transcript levels are reduced, suggesting that EDM2 is either a direct or an indirect regulator …
Mutations of EDM2 phenocopy RPP7 mutations, but do not affect other tested disease resistance genes. ...In edm2 mutants both c …
The PHD-finger module of the Arabidopsis thaliana defense regulator EDM2 can recognize triply modified histone H3 peptides.
Tsuchiya T, Eulgem T. Tsuchiya T, et al. Plant Signal Behav. 2014;9(7):e29202. doi: 10.4161/psb.29202. Plant Signal Behav. 2014. PMID: 25763495 Free PMC article.
However, how EDM2 is recruited to its genomic target sites and how it affects H3K9me2 levels is unknown. Here we show the PHD-finger module of EDM2 to recognize histone H3 bearing certain combinations of 3 distinct PHMs. ...
However, how EDM2 is recruited to its genomic target sites and how it affects H3K9me2 levels is unknown. Here we show the PHD-finger …
Arabidopsis EDM2 promotes IBM1 distal polyadenylation and regulates genome DNA methylation patterns.
Lei M, La H, Lu K, Wang P, Miki D, Ren Z, Duan CG, Wang X, Tang K, Zeng L, Yang L, Zhang H, Nie W, Liu P, Zhou J, Liu R, Zhong Y, Liu D, Zhu JK. Lei M, et al. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):527-32. doi: 10.1073/pnas.1320106110. Epub 2013 Nov 18. Proc Natl Acad Sci U S A. 2014. PMID: 24248388 Free PMC article.
A forward genetics screen led to the identification of the putative chromatin regulator Enhanced Downy Mildew 2 (EDM2) as a cellular antisilencing factor and regulator of genome DNA methylation patterns. ...Because of its role in maintaining IBM1 expression, EDM2 is …
A forward genetics screen led to the identification of the putative chromatin regulator Enhanced Downy Mildew 2 (EDM2) as a cellular …
Co-option of EDM2 to distinct regulatory modules in Arabidopsis thaliana development.
Tsuchiya T, Eulgem T. Tsuchiya T, et al. BMC Plant Biol. 2010 Sep 14;10:203. doi: 10.1186/1471-2229-10-203. BMC Plant Biol. 2010. PMID: 20840782 Free PMC article.
Microarray data further support regulatory interactions between WNK8 and EDM2. The fact that the effects of EDM2 and WNK8 on leaf pavement cell formation and leaf expansion are co-directional, while WNK8 counteracts the promoting effect of EDM2 on floral tran …
Microarray data further support regulatory interactions between WNK8 and EDM2. The fact that the effects of EDM2 and WNK8 on l …
37 results