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Quoted phrase not found in phrase index: "steoroids"
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HPTE-Induced Embryonic Thymocyte Death and Alteration of Differentiation Is Not Rescued by ERalpha or GPER Inhibition but Is Exacerbated by Concurrent TCR Signaling.
Avellaneda E, Lim A, Moeller S, Marquez J, Escalante Cobb P, Zambrano C, Patel A, Sanchez V, Godde K, Broussard C. Avellaneda E, et al. Int J Mol Sci. 2021 Sep 20;22(18):10138. doi: 10.3390/ijms221810138. Int J Mol Sci. 2021. PMID: 34576301 Free PMC article.
Organochlorine pesticides, such as DDT, methoxychlor, and their metabolites, have been characterized as endocrine disrupting chemicals (EDCs); suggesting that their modes of action involve interaction with or abrogation of endogenous endocrine function. ... …
Organochlorine pesticides, such as DDT, methoxychlor, and their metabolites, have been characterized as endocrine disrupting chemical …
Toxicology of environmental estrogens.
Safe SH, Pallaroni L, Yoon K, Gaido K, Ross S, Saville B, McDonnellc D. Safe SH, et al. Reprod Fertil Dev. 2001;13(4):307-15. doi: 10.1071/rd00108. Reprod Fertil Dev. 2001. PMID: 11800169 Review.
There has been particular concern regarding synthetic estrogens and their role in disrupting normal development of the male reproductive tract. Most estrogenic industrial compounds, such as bisphenol A (BPA) and nonylphenol, typically bind estrogen receptors …
There has been particular concern regarding synthetic estrogens and their role in disrupting normal development of the male reproductive …
Methoxychlor metabolite HPTE alters viability and differentiation of embryonic thymocytes from C57BL/6 mice.
Leung-Gurung L, Escalante Cobb P, Mourad F, Zambrano C, Muscato Z, Sanchez V, Godde K, Broussard C. Leung-Gurung L, et al. J Immunotoxicol. 2018 Dec;15(1):104-118. doi: 10.1080/1547691X.2018.1474978. J Immunotoxicol. 2018. PMID: 29973080 Free PMC article.
Endocrine-disrupting chemicals (EDC) are widespread in the built and natural environments. ...Embry-onic thymocytes (GD 16-18) from C57BL/6 mice were subjected to an in vitro differentiation culture that mimicked early steps in thymocyte development in the presence of 0.00 …
Endocrine-disrupting chemicals (EDC) are widespread in the built and natural environments. ...Embry-onic thymocytes (GD 16-18) from C …
Methoxychlor and its metabolite HPTE inhibit cAMP production and expression of estrogen receptors alpha and beta in the rat granulosa cell in vitro.
Harvey CN, Chen JC, Bagnell CA, Uzumcu M. Harvey CN, et al. Reprod Toxicol. 2015 Jan;51:72-8. doi: 10.1016/j.reprotox.2014.12.001. Epub 2014 Dec 27. Reprod Toxicol. 2015. PMID: 25549949 Free PMC article.
The major metabolite of the estrogenic pesticide methoxychlor (MXC) HPTE is a stronger ESR1 agonist than MXC and acts also as an ESR2 antagonist. In granulosa cells (GCs), FSH stimulates estradiol via the second messenger cAMP. HPTE inhibits estradi …
The major metabolite of the estrogenic pesticide methoxychlor (MXC) HPTE is a stronger ESR1 agonist than MXC and acts also as …
Estrogenic activity of bisphenol A and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) demonstrated in mouse uterine gene profiles.
Hewitt SC, Korach KS. Hewitt SC, et al. Environ Health Perspect. 2011 Jan;119(1):63-70. doi: 10.1289/ehp.1002347. Epub 2010 Sep 8. Environ Health Perspect. 2011. PMID: 20826375 Free PMC article.
METHODS: Uterine RNA from ovariectomized wild-type mice, estrogen receptor alpha (ERalpha) knockout (alphaERKO) mice, and mice expressing a DNA-binding-deficient ERalpha (KIKO) treated with E2, E3, BPA, or HPTE for 2 or 24 hr was analyzed by microarray …
METHODS: Uterine RNA from ovariectomized wild-type mice, estrogen receptor alpha (ERalpha) knockout (alphaERKO) mice, and mice …
Effects of methoxychlor and its metabolite 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on 11β-hydroxysteroid dehydrogenase activities in vitro.
Guo J, Deng H, Li H, Zhu Q, Zhao B, Chen B, Chu Y, Ge RS. Guo J, et al. Toxicol Lett. 2013 Mar 27;218(1):18-23. doi: 10.1016/j.toxlet.2013.01.002. Epub 2013 Jan 17. Toxicol Lett. 2013. PMID: 23333641
Human placental and rat kidney microsomes were used for 11beta-HSD2 activity. The IC(50) values on human 11beta-HSD1 by MXC and HPTE were 1.910.07 and 8.88 0.08 muM, respectively. HPTE inhibited rat 11beta-HSD1 with IC(50) of 9.150.05muM, while MXC did not inhibit t …
Human placental and rat kidney microsomes were used for 11beta-HSD2 activity. The IC(50) values on human 11beta-HSD1 by MXC and HPTE …
CYP polymorphisms and pathological conditions related to chronic exposure to organochlorine pesticides.
Docea AO, Vassilopoulou L, Fragou D, Arsene AL, Fenga C, Kovatsi L, Petrakis D, Rakitskii VN, Nosyrev AE, Izotov BN, Golokhvast KS, Zakharenko AM, Vakis A, Tsitsimpikou C, Drakoulis N. Docea AO, et al. Toxicol Rep. 2017 May 26;4:335-341. doi: 10.1016/j.toxrep.2017.05.007. eCollection 2017. Toxicol Rep. 2017. PMID: 28959657 Free PMC article. Review.
OCs are persistent organic pollutants with bioaccumulative and lipophilic characteristics. They can act as endocrine disruptors and perturb cellular mechanisms. Prolonged exposure to OCs has been associated with different pathological manifestations. ...
OCs are persistent organic pollutants with bioaccumulative and lipophilic characteristics. They can act as endocrine disruptors and p …
Bisphenol AF: Halogen bonding effect is a major driving force for the dual ERalpha-agonist and ERbeta-antagonist activities.
Liu X, Suyama K, Shiki J, Torikai K, Nose T, Shimohigashi M, Shimohigashi Y. Liu X, et al. Bioorg Med Chem. 2020 Feb 1;28(3):115274. doi: 10.1016/j.bmc.2019.115274. Epub 2019 Dec 18. Bioorg Med Chem. 2020. PMID: 31879182
17beta-Estradiol (E2) is a natural steroid ligand for the structurally and physiologically independent estrogen receptors (ERs) ERalpha and ERbeta. We recently observed that CF(3)-containing bisphenol AF (BPAF) works as an agonist for ERalpha but as an …
17beta-Estradiol (E2) is a natural steroid ligand for the structurally and physiologically independent estrogen receptors (ERs …
Methoxychlor as a model for environmental estrogens.
Cummings AM. Cummings AM. Crit Rev Toxicol. 1997 Jul;27(4):367-79. doi: 10.3109/10408449709089899. Crit Rev Toxicol. 1997. PMID: 9263644 Review.
Estrogens can have a variety of physiological effects, especially on the reproductive system. Chemicals with estrogenic activity that are present in the environment may thus be considered potentially hazardous to development and/or reproduction. Methoxychlor is one …
Estrogens can have a variety of physiological effects, especially on the reproductive system. Chemicals with estrogenic activi …
The methoxychlor metabolite, HPTE, inhibits rat luteal cell progesterone production.
Akgul Y, Derk RC, Meighan T, Rao KM, Murono EP. Akgul Y, et al. Reprod Toxicol. 2011 Jul;32(1):77-84. doi: 10.1016/j.reprotox.2011.05.013. Epub 2011 Jun 2. Reprod Toxicol. 2011. PMID: 21664964
However, HPTE did not alter mRNA and protein levels of P450scc. Compounds acting as estrogen (17 beta-estradiol, bisphenol-A or octylphenol), antiestrogen (ICI) or antiandrogen (monobutyl phthalate, flutamide or M-2) added alone to luteal cells did not …
However, HPTE did not alter mRNA and protein levels of P450scc. Compounds acting as estrogen (17 beta-estradiol, bisphe …
64 results