Wine by the glass on weekdays is $6 from 4 p.m. to 6 p.m. in this intimate Irving Street wine bar at 7th Avenue. Four or five happy hour reds and whites representing both New World and Old are listed on the menu from softest to most powerful, so you can judge your preferences. Small plates, cheese platters, and flatbreads to accompany.

As both a neighborhood bar and a destination bistro perched at the intersection of Nob Hill, Russian Hill, and Chinatown, Mason Pacific is balancing its multiple personalities. Either way, watch Powell-Hyde cable cars clamber past while enjoying 50 percent off bottles on the (fairly pricey) daily market list, every day from 5 p.m. to 6 p.m. and again from 9 p.m. until midnight.  

The Marina is home to a mellow yellow frontage for a candlelit wine bar called Nectar. While some of the city’s wine bars are closed on Mondays, this one starts off the week right with Nectar’s Monday signature wine flights (Pinot Envy, Anything But Chard, Bad Ass Red) slashed by 50 percent all night. Tasty black truffle popcorn goes well with muted movie wall projections.

On the edge of Hayes Valley, this cozy wine bar is super handy before a performance at SFJazz, a lecture at Nourse Theater, or even a wedding at City Hall. The emphasis is on organic wines, changing weekly. Take advantage of half price ($17) for half bottle carafes during happy hour from 4:30 p.m. to 7 p.m. every day (closed on Sundays), and take one dollar off all small plate food items with an accent on vegetarian and vegan.

A vintage 48-star American flag dominates the interiors where rustic Americana translates into Tenderknob tavern. A two-hour happy hour begins every day at 5 p.m., further enhanced on Wednesdays when bottles of wine are half price. Two facts: the walking distance to Union Square and open until 2 a.m., are not lost on the Moscone crowd.

Unlike laid-back gastropubs on the other side of the pond, “sharp” is the way Tipsy Pig describes the timing of their happy hour offerings. Don’t dawdle to score half-priced bottles of wine from 5 p.m. to 7 p.m. on Monday through Thursday evenings, and do synchronize your watch to order discounted comfort food (including nearly world famous mac n’ cheese) served from 5:30 p.m. to 6:30 p.m.

This spot a surprise off the beaten track, and in the shadow of Trader Joe’s and City Target on Geary. The light-filled, high-ceilinged, palm-dotted space is reminiscent of Paris, with its vintage terracotta tiles and old light fixtures from a French railway station. A changing menu of 30 wines by the glass mixes up classic with emerging from the USA, France, Italy, and Spain. All wines on tap are half-price every Tuesday through Friday from 3 p.m. to 5:30 p.m.

The Dogpatch sister of Pause mirrors the happy hour formula. Half-price carafes of sustainable and organic wines from small, family-owned and -operated wineries are accompanied by (mainly) vegetarian small bites. Win, place, or show in the Tuesday night trivia quiz to subtract a percentage off your bill.