Photophysical Mechanism for Quantum Dots-Induced Bacterial Growth Inhibition
Quantum dots-induced cell growth inhibition effect and its photophysical mechanism were investigated in this report. Cell growth curve and atomic force microscopy show that QDs block cell division to inhibit the growth of bacterial cells. On the basis of combined biological and physical
discoveries from cytochrome c reduction assay, hydrodynamic size, photoluminescence and UV-visible spectrometry, a photophysical mechanism involving a polypeptide or amino acid adsorption-mediated fluorescence and reactive oxygen species quenching process is proposed. The photophysical mechanism
may not only provide physical insight of QDs-induced toxicity, but also render QDs potentials in antimicrobial and cancer photodynamic therapy applications.
Keywords: NANOTOXICITY; PHOTOPHYSICAL MECHANISM; QUANTUM DOTS; REACTIVE OXYGEN SPECIES
Document Type: Short Communication
Publication date: 01 May 2009
- Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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