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1983 1
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Quoted phrase not found in phrase index: "steoroids"
Page 1
Hepatic tumor-promoting ability of 3,3',4,4',5,5'-hexabromobiphenyl: the interrelationship between toxicity, induction of hepatic microsomal drug metabolizing enzymes, and tumor-promoting ability.
Jensen RK, Sleight SD, Aust SD, Goodman JI, Trosko JE. Jensen RK, et al. Toxicol Appl Pharmacol. 1983 Nov;71(2):163-76. doi: 10.1016/0041-008x(83)90333-2. Toxicol Appl Pharmacol. 1983. PMID: 6314605
Female Sprague-Dawley rats were fed diets containing 0, 0.01, 0.1, or 1.0 mg/kg 3,3',4,4',5,5'-hexabromobiphenyl (345-HBB) for 140 days after a 70% partial hepatectomy and diethylnitrosamine administration (10 mg/kg body weight) to …
Female Sprague-Dawley rats were fed diets containing 0, 0.01, 0.1, or 1.0 mg/kg 3,3',4,4',5,5'- …
Effects of PCBs and related compounds on hepatocarcinogenesis in rats and mice.
Sleight S. Sleight S. Environ Health Perspect. 1985 May;60:35-9. doi: 10.1289/ehp.856035. Environ Health Perspect. 1985. PMID: 2992924 Free PMC article. Review.
A toxic congener, 3,3', 4,4', 5,5'-HBB, also was assessed for tumor-promoting activity. This congener, though not in FM, is similar to TCDD, in that both cause 3-methylcholanthrene (MC)-type induction of hepatic microsomal enzymes and produce similar toxic responses. ...Th …
A toxic congener, 3,3', 4,4', 5,5'-HBB, also was assessed for tumor-promoting activity. This congener, though not in FM, is similar t …
Sequential study on the synergistic effects of 2,2',4,4',5,5'-hexabromobiphenyl and 3,3',4,4',5,5'-hexabromobiphenyl on hepatic tumor promotion.
Jensen RK, Sleight SD. Jensen RK, et al. Carcinogenesis. 1986 Oct;7(10):1771-4. doi: 10.1093/carcin/7.10.1771. Carcinogenesis. 1986. PMID: 2875811
Thirty days later, rats were randomly assigned to groups and fed a basal diet or the basal diet containing 10 p.p.m. 2,2',4,4',5,5'-hexabromobiphenyl (245-HBB), 0.1 p.p.m. 3,3',4,4',5,5'-hexabromobiphenyl (345-HBB) or 10 p.p.m. 245 …
Thirty days later, rats were randomly assigned to groups and fed a basal diet or the basal diet containing 10 p.p.m. 2,2',4,4',5,5'-hexabrom …
Genetic differences in lethality of newborn mice treated in utero with coplanar versus non-coplanar hexabromobiphenyl.
Curran CP, Miller KA, Dalton TP, Vorhees CV, Miller ML, Shertzer HG, Nebert DW. Curran CP, et al. Toxicol Sci. 2006 Feb;89(2):454-64. doi: 10.1093/toxsci/kfj048. Epub 2005 Nov 16. Toxicol Sci. 2006. PMID: 16291824
Coplanar PBBs bind to the aryl hydrocarbon receptor (AHR) in vertebrates. We compared the coplanar PBB, 3,3',4,4',5,5'-hexabromobiphenyl (cHBB), with its stereoisomer, the non-coplanar PBB, 2,2',4,4'6,6'-hexabromobiphenyl (ncHBB), …
Coplanar PBBs bind to the aryl hydrocarbon receptor (AHR) in vertebrates. We compared the coplanar PBB, 3,3',4,4 …
Induction of three histochemically distinct populations of hepatic foci in C57BL/6J mice.
Hanigan MH, Winkler ML, Drinkwater NR. Hanigan MH, et al. Carcinogenesis. 1993 May;14(5):1035-40. doi: 10.1093/carcin/14.5.1035. Carcinogenesis. 1993. PMID: 8099313
Additional groups of female mice were ovariectomized at 6 weeks of age with or without subsequent chronic treatment with testosterone. All the animals were killed at 24 weeks of age and serial liver sections were stained for glucose-6-phosphatase (G6Pase) or GGT. Both t …
Additional groups of female mice were ovariectomized at 6 weeks of age with or without subsequent chronic treatment with testosterone …
Stimulation of in vivo hepatic uptake and in vitro hepatic binding of [125I]2-lodo-3,7,8-trichlorodibenzo-p-dioxin by the administration of agonist for the Ah receptor.
Poland A, Teitelbaum P, Glover E, Kende A. Poland A, et al. Mol Pharmacol. 1989 Jul;36(1):121-7. Mol Pharmacol. 1989. PMID: 2546046
In congenic C57BL/6J (Ahd/Ahd) mice, which express the lower affinity Ah receptor, the ED50 values for all three responses were shifted to approximately 10-fold higher doses. 3,3',4,4',5,5'-Hexabromobiphenyl, a weak agonist for the …
In congenic C57BL/6J (Ahd/Ahd) mice, which express the lower affinity Ah receptor, the ED50 values for all three responses were shifted to a …
Specific binding of polyhalogenated aromatic hydrocarbon inducers of cytochrome P-450d to the cytochrome and inhibition of its estradiol 2-hydroxylase activity.
Voorman R, Aust SD. Voorman R, et al. Toxicol Appl Pharmacol. 1987 Aug;90(1):69-78. doi: 10.1016/0041-008x(87)90307-3. Toxicol Appl Pharmacol. 1987. PMID: 2820083
Five other halogenated aromatic hydrocarbon inducers of cytochrome P-450d, bearing steric similarity to HBB (including 2,3,7,8-tetrachlorodibenzo-p-dioxin), were associated with cytochrome P-450d when used to induce cytochrome P-450d in rats. HBB inhibited estradiol 2-hydr …
Five other halogenated aromatic hydrocarbon inducers of cytochrome P-450d, bearing steric similarity to HBB (including 2,3,7,8-tetrachlorodi …
Inducers of cytochrome P-450d: influence on microsomal catalytic activities and differential regulation by enzyme stabilization.
Voorman R, Aust SD. Voorman R, et al. Arch Biochem Biophys. 1988 Apr;262(1):76-84. doi: 10.1016/0003-9861(88)90170-1. Arch Biochem Biophys. 1988. PMID: 2833177
The interaction of isosafrole, 3,4,5,3',4',5'-hexabromobiphenyl (HBB) and hexachlorobiphenyl (HCB) with cytochrome P-450d was evaluated by characterization of estradiol 2-hydroxylase activity. Displacement of the isosafrole metabolite from microsomal cytochrome P-450d deri …
The interaction of isosafrole, 3,4,5,3',4',5'-hexabromobiphenyl (HBB) and hexachlorobiphenyl (HCB) with cytochrome P-450d was evaluated by c …
Polybrominated biphenyls.
[No authors listed] [No authors listed] IARC Monogr Eval Carcinog Risk Chem Hum. 1986;41:261-92. IARC Monogr Eval Carcinog Risk Chem Hum. 1986. PMID: 3034763 No abstract available.
Quantification of nuclear pores in tumor promoter-induced hepatic nodules in rats: a freeze-fracture study.
Evans MG. Evans MG. J Toxicol Environ Health. 1988;25(4):471-7. doi: 10.1080/15287398809531225. J Toxicol Environ Health. 1988. PMID: 2848948
Twelve-week-old outbred female Sprague-Dawley rats weighing 190-210 g were partially hepatectomized and given diethylnitrosamine intraperitoneally (10 mg/kg) 24 h later. Thirty days later, rats were fed a diet containing tumor-promoting doses of two polybrominated biphenyl …
Twelve-week-old outbred female Sprague-Dawley rats weighing 190-210 g were partially hepatectomized and given diethylnitrosamine intraperito …